Guy A. Howard

Research Professor of
Medicine and Biochemistry

Ph.D. (1970) University of Oregon

Mineral metabolism in bone,
osteoporosis

(305) 575-3388, 
FAX: 305-575-3365

ghoward1@med.miami.edu

Representative Publications:

·         Qadan LR, Perez-Stable C, Anderson C, D’Ippolito G, Herron A, Howard GA, Roos BA: 2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer.  Biochem Biophys Res Commun 285:1259-1266, 2001

·         D’Ippolito G, Schiller PC, Balkan W, Roos BA, Howard GA: Cooperative anabolic actions of hepatocyte growth factor and 1,25-dihydroxyvitamin D₃ in osteoblastic differentiation of human vertebral marrow stromal fibroblasts.  Bone 31:269-275, 2002

·         Perez-Stable CM, Schwartz GG, Farinas A, Finegold M, Binderup L, Howard GA, Roos BA: The G/T-15 Transgenic Mouse Model of Androgen-Independent Prostate Cancer: Target Cells of Carcinogenesis and the Effect of the Vitamin D Analog EB 1089. Cancer Epi Biom Pre 11:555-563, 2002

·         Hernandez-Cassis C , Vogel CK, Hernandez TP, Econs MJ, Iglesias M ,  Iglesias A, Levis S, Roos BA, Howard GA, Gamarra AI: Autosomal dominant hyperostosis/osteosclerosis with high serum alkaline phosphatase activity. J Clin Endocrinol Metab 88:2650-2655, 2003

·         D’Ippolito G, Diabira S, Howard GA, Menei P, Roos BA, Schiller PC: Marrow-isolated Adult Multilineage Inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci 117:2971-2981, 2004

·         Balkan W, Burnstein KL, Schiller PC, Perez-Stable C, D’Ippolito G, Howard GA, Roos BA:  Androgen-induced mineralization by MC3T3-E1 osteoblastic cells reveals a critical window of hormone responsiveness. Biochem Biophys Res Commun 328:783-789, 2005

·         D’Ippolito G, Howard GA, Roos BA, Schiller PC: Sustained Stromal Stem Cell Self-Renewal and Osteoblastic Differentiation During Aging. Rejuvenation Res 9:10-19, 2006

·         D’Ippolito G, Diabira S, Howard GA, Roos BA, Schiller PC: Low Oxygen Tension Inhibits Osteogenic Differentiation and Enhances Stemness of Human MIAMI Cells. Bone 39:513-522, 2006

·         D’Ippolito G, Howard GA, Roos BA, Schiller PC: Isolation and characterization of marrow-isolated adult multilineage inducible (MIAMI) cells. Exptl Hematol 34:1608-1610, 2006